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(AP) -- Kyle Weems scored 25 of his career-high 31 points in the second half, Anthony Downing scored a career-high 26 and Missouri State opened defense of its Missouri Valley Conferencetitle with a 77-65 upset of No. 21 Creighton on Wednesday night.

Downing's 23-footer as the shot clock ran out with 1:11 left that gave the Bears (asterisk)8-5, 1-0) a six-point lead.

Jarmar Gulley had 12 points for the Bears.

National scoring leader Doug McDermott finished with 19 points for Creighton (10-2, 0-1) but he only made one free throw after his 3-pointer with 10:39 left gave the Bluejays a short-lived 51-50 lead.

McDermott had his streak of 20-point games end at 10.

Antoine Young added 13 points and Josh Jones had 11 for Creighton.

Missouri State won for the first time in six road games against ranked teams

Preseason MVC favorite Creighton lost at home as a ranked team for the first time in 19 games since 1975.

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