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(AP) - The Indianapolis Colts are winless no longer.

Dan Orlovsky threw one touchdown pass and the key block on an 80-yard TD run, leading the Colts to their first win of the season, 27-13 over Tennessee on Sunday.

Indianapolis (1-13) avoided becoming the second team in NFL history to go 0-16.

The loss dealt a serious blow to the Titans' playoff hopes.

Quarterback Matt Hasselbeck was picked off twice and Chris Johnson rushed for only 55 yards for Tennessee (7-7).

Orlovsky gave Indy a 10-6 lead with an 18-yard TD pass to Reggie Wayne in the third quarter, and Jacob Lacey made it 17-6 with a 32-yard interception return for a TD.

Jake Locker got the Titans within 20-13 with a 7-yard TD pass to Nate Washington with 3:43 to go.

But on the next play, with Donald Brown reversing field, Orlovsky threw a block that helped Brown get to the corner and he sprinted 80 yards to seal the win.